Arora Vikas, Yadav Vishal, Aggarwal Manisha, Mandal Ghanashyam, Chakraborty Arnab, Dewan A K, Kamboj Meenakshi
Department of Head and Neck Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, 110085 India.
Department of Patho Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, 110085 India.
Indian J Otolaryngol Head Neck Surg. 2023 Dec;75(4):3765-3769. doi: 10.1007/s12070-023-04101-9. Epub 2023 Jul 21.
There have been many disputes about the definition, diagnosis, therapy, and prognosis of collision tumours.
We describe a rare patient with a collision tumour consisting of high-grade neuroendocrine carcinoma (NEC) and squamous cell carcinoma (SCC) in the right nasal cavity and paranasal sinus. She received surgery, concurrent chemoradiotherapy, and then two cycles of palliative chemotherapy. Follow-up at 26 months after diagnosis showed that this patient experienced a complete response with no signs of recurrence or metastasis. A literature review of previous 27 cases diagnosed with collision tumour of NEC and SCC in the head and neck was also undertaken.
It is highly challenging to manage collision tumours because these are two morphologically and etiologically distinct tumours. Well-designed multimodality therapy including surgery and chemoradiotherapy might lead to a long survival in these patients.
关于碰撞瘤的定义、诊断、治疗及预后存在诸多争议。
我们描述了一名罕见患者，其右侧鼻腔及鼻窦存在由高级别神经内分泌癌（NEC）和鳞状细胞癌（SCC）组成的碰撞瘤。她接受了手术、同步放化疗，随后进行了两个周期的姑息化疗。诊断后26个月的随访显示，该患者完全缓解，无复发或转移迹象。我们还对先前诊断为头颈部NEC和SCC碰撞瘤的27例病例进行了文献综述。
处理碰撞瘤极具挑战性，因为这是两种形态学和病因学上截然不同的肿瘤。精心设计的包括手术及放化疗的多模式治疗可能使这些患者获得长期生存。
