Velnar Tomaz, Bailey T, Smrkolj V
Department of Neurosurgery, University Medical Centre Maribor, Maribor, Slovenia.
J Int Med Res. 2009 Sep-Oct;37(5):1528-42. doi: 10.1177/147323000903700531.
Wound healing remains a challenging clinical problem and correct, efficient wound management is essential. Much effort has been focused on wound care with an emphasis on new therapeutic approaches and the development of technologies for acute and chronic wound management. Wound healing involves multiple cell populations, the extracellular matrix and the action of soluble mediators such as growth factors and cytokines. Although the process of healing is continuous, it may be arbitrarily divided into four phases: (i) coagulation and haemostasis; (ii) inflammation; (iii) proliferation; and (iv) wound remodelling with scar tissue formation. The correct approach to wound management may effectively influence the clinical outcome. This review discusses wound classification, the physiology of the wound healing process and the methods used in wound management.
伤口愈合仍然是一个具有挑战性的临床问题，正确、有效的伤口管理至关重要。许多努力都集中在伤口护理上，重点是新的治疗方法以及急性和慢性伤口管理技术的开发。伤口愈合涉及多种细胞群体、细胞外基质以及生长因子和细胞因子等可溶性介质的作用。虽然愈合过程是连续的，但可任意分为四个阶段：（i）凝血和止血；（ii）炎症；（iii）增殖；以及（iv）形成瘢痕组织的伤口重塑。正确的伤口管理方法可有效影响临床结果。本综述讨论了伤口分类、伤口愈合过程的生理学以及伤口管理中使用的方法。
