Academy of Biology, College of Science and Technology, Universidad Autónoma de la Ciudad de México-San Lorenzo Tezonco, Av. Prolongación San Isidro 151, Col. San Lorenzo Tezonco, Deleg., Iztapalapa, CP 09790, México.
Pharmacol Biochem Behav. 2010 Feb;94(4):503-9. doi: 10.1016/j.pbb.2009.11.004. Epub 2009 Nov 17.
A number of studies have reported an association between smoking and depression, and several reports suggest that nicotine (NIC) may act as an antidepressant. The present study was designed to determine whether the effects of NIC on sleep-wake patterns in rats are similar to those of the antidepressant fluoxetine (FLX), a selective serotonin reuptake inhibitor. Male rats were chronically implanted with a standard set of electrodes for sleep recording. We compared the effects of antidepressive doses of NIC, FLX and the combination of both drugs on sleep-wake pattern in rats subjected to one day, one week and two weeks of administration, as well as after the withdrawal of the two-week treatment. The changes observed in our study in an 8-h sleep recording period during one day, one week and two weeks of NIC administration are very similar to those observed in the rats that received FLX, which led to a decrease in both slow wave sleep II and rapid eye movement (REM) sleep as a consequence of an increase in wakefulness. In addition, all treatments also induced a significant lengthening of REM sleep latency onset. These data suggest that the antidepressant-like action of NIC could be caused by its arousing properties.
许多研究报告指出吸烟与抑郁之间存在关联，并且有几项报告表明尼古丁（NIC）可能具有抗抑郁作用。本研究旨在确定 NIC 对大鼠睡眠-觉醒模式的影响是否与抗抑郁药氟西汀（FLX）相似，FLX 是一种选择性 5-羟色胺再摄取抑制剂。雄性大鼠被慢性植入用于睡眠记录的标准电极组。我们比较了抗抑郁剂量的 NIC、FLX 以及这两种药物联合使用对接受一天、一周和两周给药的大鼠睡眠-觉醒模式的影响，以及在两周治疗结束后的影响。在一天、一周和两周的 NIC 给药期间 8 小时睡眠记录期间观察到的变化与接受 FLX 的大鼠非常相似，这导致慢波睡眠 II 和快速眼动（REM）睡眠减少，这是由于清醒时间增加所致。此外，所有治疗方法还导致 REM 睡眠潜伏期起始显著延长。这些数据表明，NIC 的抗抑郁样作用可能是由于其唤醒特性所致。
