2006 年 1 月至 2007 年 12 月中国大陆住院腹泻患儿中 G9 轮状病毒株的分子流行病学研究。

Molecular epidemiology of G9 rotavirus strains in children with diarrhoea hospitalized in Mainland China from January 2006 to December 2007.

机构信息

State Key Laboratory of Molecular Virology and Genetic Engineering, National Institute for Viral Disease Control and Prevention, China CDC, 100 Ying-Xin Street, Xuan Wu District, Beijing 100052, PR China.

出版信息

Vaccine. 2009 Nov 20;27 Suppl 5:F40-5. doi: 10.1016/j.vaccine.2009.08.073.

DOI:10.1016/j.vaccine.2009.08.073

PMID:19931718

Abstract

Rotavirus was detected in 52% of 2328 stool specimens collected from children with acute gastroenteritis admitted to three sentinel hospitals in Mainland China from January 2006 to December 2007. G3P[8] (42%) was the most common strain. Despite being common globally, only 18 (2%) G9-positive samples were identified. The VP7, VP4, VP6, and NSP4 genes were sequences for 13 of the G9 strains with G9P[8] being most common and showing the same origin as G9 strains reported in other countries. One G9P[6] strain was possibly derived by reassortment between earlier Chinese G9 strains and more recent local P[6] strains.

摘要

轮状病毒在 2006 年 1 月至 2007 年 12 月中国大陆三家监测医院收治的急性肠胃炎患儿的 2328 份粪便标本中检出率为 52%。G3P[8]（42%）是最常见的毒株。尽管轮状病毒在全球范围内很常见，但仅鉴定出 18 份（2%）G9 阳性样本。其中 13 株 G9 分离株的 VP7、VP4、VP6 和 NSP4 基因序列完全一致，G9P[8]是最常见的基因型，与其他国家报道的 G9 株同源性较高。一株 G9P[6]分离株可能是由早期中国 G9 株与近期本地 P[6]株重组而来。