多发性硬化症中的脂质自身反应性。

Lipid autoreactivity in multiple sclerosis.

机构信息

Harvard College, 211 Currier Mail Center, 64 Linnaean Street, Cambridge, MA 02138-1502, United States.

出版信息

Med Hypotheses. 2010 Mar;74(3):433-42. doi: 10.1016/j.mehy.2009.10.003. Epub 2009 Nov 22.

DOI:10.1016/j.mehy.2009.10.003

PMID:19932569

Abstract

Lipids comprise over 70% of the myelin sheath but have been largely underinvestigated as autoantigens in multiple sclerosis (MS). This paper cites evidence for the involvement of lipid autoreactivity in MS and details how self lipid cross-reactivity may also contribute to the development of type 1 diabetes and autoimmune thyroid disorders (both of which have been associated with MS). A further analysis of myelin chemistry suggests several mechanisms by which infection may contribute to etiology and trigger lipid autoreactivity via molecular mimicry. This analysis may aid the development of new therapies for autoimmune diseases.

摘要

脂质占髓鞘的 70%以上，但作为多发性硬化症 (MS) 的自身抗原，它们在很大程度上尚未得到充分研究。本文引用了脂质自身反应性参与 MS 的证据，并详细说明了自身脂质交叉反应性如何也可能导致 1 型糖尿病和自身免疫性甲状腺疾病的发展（这两者都与 MS 有关）。对髓鞘化学的进一步分析表明，感染可能通过分子模拟导致病因学和触发脂质自身反应的几种机制。这种分析可能有助于为自身免疫性疾病开发新的治疗方法。