Appelberg R, Pedrosa J M, Silva M T
Centro de Citologia Experimental, University of Porto, Portugal.
Clin Exp Immunol. 1991 Feb;83(2):231-6. doi: 10.1111/j.1365-2249.1991.tb05620.x.
Persistent peritoneal granulocytosis and elevated macrophage counts have been found in nine mouse strains from 8 to 90 days after infection with Mycobacterium avium. Peritoneal granulocytosis was higher in M. avium-resistant BALB/c. Bcgr (C.D2) mice, compared with congenic M. avium-susceptible BALB/c (Bcgs) animals. Although maximal granulocytosis values were not related to virulence of the inocula, the kinetics of the granulocytic response varied with the virulence of M. avium. Following infections by avirulent (rough) strains of M. avium, the peritoneal granulocytosis progressively declined in BALB/c and C3H/He mice. A similar decline in granulocyte number was observed in resistant C3H/He mice infected with virulent M. avium (smooth transparent strain). In both instances the decline in the peritoneal granulocytosis was associated with a progressive elimination of the inoculum. In the susceptible BALB/c mice, virulent M. avium strains induced progressive infection accompanied with a rapid decline in granulocyte number, whereas the infection with attenuated M. avium, which caused a chronic infection, induced persistent granulocytosis. The ability to recruit granulocytes following the intraperitoneal inoculation of a phlogistic substance (casein hydrolysate) was decreased in infected susceptible but not in infected resistant mice at 90 days of infection with virulent M. avium.
在感染鸟分枝杆菌后的8至90天内，在9个小鼠品系中发现了持续性腹膜粒细胞增多和巨噬细胞计数升高。与同基因的对鸟分枝杆菌易感的BALB/c（Bcgs）动物相比，对鸟分枝杆菌有抗性的BALB/c.Bcgr（C.D2）小鼠的腹膜粒细胞增多更为明显。尽管最大粒细胞增多值与接种物的毒力无关，但粒细胞反应的动力学随鸟分枝杆菌的毒力而变化。在用无毒力（粗糙型）鸟分枝杆菌菌株感染后，BALB/c和C3H/He小鼠的腹膜粒细胞增多逐渐下降。在用有毒力的鸟分枝杆菌（光滑透明菌株）感染的抗性C3H/He小鼠中也观察到粒细胞数量有类似下降。在这两种情况下，腹膜粒细胞增多的下降都与接种物的逐渐清除有关。在易感的BALB/c小鼠中，有毒力的鸟分枝杆菌菌株引起进行性感染，同时粒细胞数量迅速下降，而用减毒的鸟分枝杆菌感染导致慢性感染，会引起持续性粒细胞增多。在用有毒力的鸟分枝杆菌感染90天时，感染的易感小鼠腹腔内接种炎性物质（酪蛋白水解物）后募集粒细胞的能力下降，但感染的抗性小鼠则未出现这种情况。
