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需要采取紧急行动来改善英格兰老年人的维生素 D 状况!

Urgent action needed to improve vitamin D status among older people in England!

机构信息

Department of Epidemiology and Public Health, Royal Free and University College London Medical School, UK.

出版信息

Age Ageing. 2010 Jan;39(1):62-8. doi: 10.1093/ageing/afp195. Epub 2009 Nov 23.

Abstract

BACKGROUND

the importance of vitamin D for bone health is well known, but emerging evidence also suggests that adequate vitamin D status may also be protective against non-communicable diseases. In the UK, government initiatives highlighting the importance of adequate vitamin D among older people have been in place since 1998.

OBJECTIVES

the aim of this analysis is to assess vitamin D status in people aged > or =65, living in private households in England, 2005 and make comparisons with the Health Survey for England (HSE) 2000 and the National Diet and Nutrition Survey (NDNS), 1994. We also examine associations of hypovitaminosis D [serum 25(OH)D <50 nmol/l] with demographic, geographic, lifestyle and health risk factors.

DESIGN AND SETTING

a nationally representative sample of older people living in England in 2005.

PARTICIPANTS

2,070 adults aged > or =65, living in private households taking part in the HSE 2005.

RESULTS

in the HSE 2005, mean serum 25(OH)D levels were 53 and 49 nmol/l in men and women, respectively, these levels are significantly lower than currently recommended at > or =75 nmol/l. Prevalence of vitamin D deficiency [25(OH)D <25 nmol/l] in people aged > or =65 in 2005 was 13% in women and 8% in men. Nearly two thirds (57%) of women and half of men (49%) had serum 25(OH)D <50 nmol/l. Only 16% of men and 13% of women aged > or =65 years had serum 25(OH)D levels > or =75 nmol/l. There is no improvement in vitamin D status in 2005 compared to 2000 and a significant decline in vitamin D status among men in 2005 in comparison to the 1994/1995 NDNS results. The odds of hypovitaminosis D increased by age group from those aged 75-79 to aged > or =85. Season of taking a blood sample, obesity, dark skin pigmentation, not taking vitamin supplements, cigarette smoking, poor general health and longstanding illness were all significant predictors (P < 0.05) of serum 25(OH)D status in adjusted regression models.

CONCLUSIONS

poor vitamin D status of older people continues to be a public health problem in England. Hypovitaminosis D is associated with many risk factors and poor health outcomes. There is now an urgent need for a uniform policy on assessment and dietary supplementation of vitamin D in older people to prevent poor vitamin D status and its negative consequences.

摘要

背景

维生素 D 对骨骼健康的重要性已广为人知,但新出现的证据表明,充足的维生素 D 状态也可能对非传染性疾病具有保护作用。在英国,自 1998 年以来,政府一直强调老年人摄入足够的维生素 D 的重要性。

目的

本分析旨在评估 2005 年居住在英格兰私人住宅中的>或=65 岁人群的维生素 D 状况,并与英格兰健康调查(HSE)2000 年和全国饮食与营养调查(NDNS)1994 年的结果进行比较。我们还研究了低维生素 D 血症(血清 25(OH)D <50nmol/L)与人口统计学、地理、生活方式和健康风险因素的关联。

设计和设置

2005 年英格兰代表性的老年人样本。

参与者

2070 名年龄>或=65 岁、居住在私人住宅中的 HSE 2005 年参与者。

结果

在 HSE 2005 年,男性和女性的平均血清 25(OH)D 水平分别为 53 和 49nmol/L,这两个水平明显低于目前推荐的>或=75nmol/L。2005 年,65 岁以上人群维生素 D 缺乏症(血清 25(OH)D <25nmol/L)的患病率为女性 13%,男性 8%。近三分之二(57%)的女性和一半(49%)的男性(男性)血清 25(OH)D <50nmol/L。只有 16%的男性和 13%的女性年龄>或=65 岁时血清 25(OH)D 水平>或=75nmol/L。与 2000 年相比,2005 年的维生素 D 状况并没有改善,与 1994/1995 年 NDNS 结果相比,2005 年男性的维生素 D 状况显著下降。血清 25(OH)D 状态的可能性随着年龄组从 75-79 岁增加到>或=85 岁。采血季节、肥胖、深色皮肤色素沉着、不服用维生素补充剂、吸烟、一般健康状况差和长期患病均为血清 25(OH)D 状态的显著预测因素(P <0.05)。

结论

英格兰老年人的维生素 D 状况不佳仍然是一个公共卫生问题。低维生素 D 血症与许多风险因素和不良健康结果有关。现在迫切需要制定一项关于老年人维生素 D 评估和饮食补充的统一政策,以预防维生素 D 状况不佳及其不良后果。

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