Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.
Eat Weight Disord. 2009 Jun-Sep;14(2-3):e113-20. doi: 10.1007/BF03327808.
To assess improvement in aspects of personality in patients hospitalized with anorexia nervosa (AN) and its relationship to improved depression, body mass index (BMI), and eating disorder outcome after treatment.
Twenty females hospitalized with AN completed intake and discharge assessments of BMI, depression and eating disorder severity, as well as personality pathology with the Minnesota Multiphasic Personality Inventory (MMPI-2) and the Revised NEO Personality Inventory (NEO PI-R). Clinical outcome for a subset of patients at 1-year post-hospitalization was determined.
The only factor that predicted better versus worse outcome at 1-year post-hospitalization was change in Low Self-Esteem (LSE) from the MMPI-2. Improved LSE from admission to discharge predicted remission at 1-year post-hospitalization, while worsening LSE predicted relapse. Regardless of outcome, NEO PI-R Neuroticism remained pathologically elevated in AN patients during hospitalization.
Pathological levels of neuroticism may represent a vulnerability factor for AN. In contrast, self-esteem appears to be a modifiable factor that predicts outcome following hospitalization, and may be an important target for treatment.
评估住院治疗神经性厌食症（AN）患者人格各方面的改善情况，及其与抑郁、体重指数（BMI）改善和治疗后饮食障碍结果的关系。
20 名女性住院 AN 患者完成了 BMI、抑郁和饮食障碍严重程度的入院和出院评估，以及明尼苏达多相人格问卷（MMPI-2）和修订版大五人格量表（NEO PI-R）的人格病理评估。对一组患者在住院后 1 年的临床结果进行了评估。
唯一能预测 1 年后住院治疗结果更好或更差的因素是 MMPI-2 中的低自尊（LSE）变化。从入院到出院时 LSE 的改善预示着 1 年后的缓解，而 LSE 的恶化则预示着复发。无论结果如何，在住院期间，AN 患者的 NEO PI-R 神经质仍处于病理性升高状态。
神经质可能代表 AN 的易患因素。相比之下，自尊似乎是一个可以预测住院后结果的可改变因素，可能是治疗的一个重要目标。
