Department of Person and Society, University of Liege, Belgium.
Alzheimer Dis Assoc Disord. 2009 Oct-Dec;23(4):395-400. doi: 10.1097/WAD.0b013e3181b4cf48.
The aim of this descriptive study was to estimate and compare the association between cognitive decline and quality of life (QOL) for 2 groups of dementia patients differing by place of residence: home or institution. Each subject was placed within a specific subgroup according to their Mini-Mental State Examination (MMSE) score and was evaluated by a QOL proxy-assessment [Alzheimer Disease Related Quality of Life (ADRQL)] and a dependency assessment (Katz Activities of Daily Living classification). For the "at home" and "institution" groups, global and subscale ADRQL scores showed significant differences between the 5 MMSE subgroups. Place of residence and MMSE subgroups significantly affected global and subscale ADRQL scores. The MMSE 4 to 8, 9 to 13, and 14 to 18 subgroups had ADRQL global scores significantly better in the institution group than the at home group. In contrast, the MMSE 19 to 23 and 0 to 3 subgroups had similar ADRQL global scores in both places of residence. In conclusion, there is no direct relationship between cognitive decline and QOL, and QOL does not seem to be better at home compared with the institution.
本描述性研究的目的是评估和比较两组居住场所不同的痴呆症患者认知能力下降与生活质量（QOL）之间的关联：居家或住院。每位患者都根据其简易精神状态检查（MMSE）评分被归入特定亚组，并通过生活质量代理评估[阿尔茨海默病相关生活质量（ADRQL）]和依赖评估（Katz 日常生活活动分类）进行评估。对于“居家”和“住院”组，ADRQL 的总体和子量表评分在 5 个 MMSE 亚组之间存在显著差异。居住场所和 MMSE 亚组显著影响 ADRQL 的总体和子量表评分。MMSE 4 至 8、9 至 13 和 14 至 18 分亚组的 ADRQL 总体评分在住院组显著优于居家组。相比之下，MMSE 19 至 23 和 0 至 3 分亚组在两个居住场所的 ADRQL 总体评分相似。总之，认知能力下降与 QOL 之间没有直接关系，而且 QOL 在居家环境中似乎并不比住院环境更好。
