Department of Specific Prophylaxis and Tropical Medicine, Center for Physiology, Pathophysiology and Immunology, Medical University Vienna, Vienna, Austria.
Pediatr Infect Dis J. 2010 Apr;29(4):319-23. doi: 10.1097/INF.0b013e3181c18434.
Since July 2007, rotavirus vaccinations have been subsidized in Austria for all children from the seventh week up to the sixth month of life. Vaccination coverage over the whole period was 72% with an increase to 87% in 2008.
In a sentinel network including 11 pediatric hospital wards in Austria, data of children up to 15 years of age and hospitalized due to rotavirus gastroenteritis between January 2001 and December 2008 have been collected.
The hospitalization rates of children up to 12 months of age with rotavirus gastroenteritis were 2066 x 10(-5) between 2001 and 2006 and decreased to 631 x 10(-5) in 2008. For children between 12 and 24 months of age the hospitalization rate decreased from 1822 x 10(-5) (2001-2006) to 1456 x 10(-5) in 2008. In children aged 2 to less than 5 years, incidence rates were 436 x10(-5) (2001-2006) and 461 x 10(-5) in 2008. In older children, the hospitalization rates remained unchanged. In the target population for the RV-vaccine, a decrease of hospitalization rates due to rotavirus gastroenteritis of 74% was observed compared to the era before the introduction of the vaccine. The field effectiveness of the vaccine was estimated between 61% and 98%, depending on assumptions about the vaccination status.
Within 18 months, the universal mass vaccination program against rotavirus led to a substantial decrease in the hospitalization rates of the target cohort of the immunization program in Austria.
自 2007 年 7 月以来，奥地利为所有 7 周至 6 个月大的儿童提供轮状病毒疫苗补贴。整个时期的疫苗接种覆盖率为 72%，2008 年增加到 87%。
在包括奥地利 11 家儿科医院病房的监测网络中，收集了 2001 年 1 月至 2008 年 12 月期间因轮状病毒胃肠炎住院的 15 岁以下儿童的数据。
2001 年至 2006 年期间，12 个月以下儿童轮状病毒胃肠炎的住院率为 2066x10(-5)，2008 年降至 631x10(-5)。对于 12 至 24 个月大的儿童，住院率从 2001-2006 年的 1822x10(-5)降至 2008 年的 1456x10(-5)。2 至 4 岁以下儿童的发病率为 436x10(-5)（2001-2006 年）和 2008 年的 461x10(-5)。在较大的儿童中，住院率保持不变。在 RV 疫苗的目标人群中，与疫苗引入前相比，轮状病毒胃肠炎的住院率下降了 74%。疫苗的现场有效性估计在 61%至 98%之间，具体取决于对疫苗接种状况的假设。
在 18 个月内，针对轮状病毒的普遍大规模疫苗接种计划导致奥地利免疫计划目标人群的住院率大幅下降。
