Department of Pediatrics, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences (USUHS), 4301 Jones Bridge Rd, Bethesda, MD 20814, USA.
Vaccine. 2011 Jan 17;29(4):650-9. doi: 10.1016/j.vaccine.2010.11.041. Epub 2010 Dec 1.
We conducted a retrospective review of all U.S. military dependents less than 5 years old hospitalized with rotavirus-associated gastroenteritis from July 2003 to June 2009. The two post-vaccine seasons showed a significant reduction of 62.4% (95% CI, 58.6-65.8, P<0.001) in rotavirus gastroenteritis hospitalization rate compared to the three pre-vaccine seasons. Infants less than 12 months old showed the greatest reduction in incidence at 75.3%. A substantial decrease was also seen in unvaccinated children as well. Vaccine efficacy against hospitalization was 86.0% (95% CI, 77.7-91.3) after just a single dose. The overwhelming majority of children hospitalized for rotavirus since the introduction of the vaccine (ranging from 91.8 to 100% per season) had not received any of the rotavirus vaccine series.
我们对 2003 年 7 月至 2009 年 6 月期间所有因轮状病毒相关性肠胃炎住院的 5 岁以下美国军人子女进行了回顾性审查。与疫苗接种前的三个季节相比，疫苗接种后的两个季节轮状病毒肠胃炎住院率显著下降 62.4%（95%CI，58.6-65.8，P<0.001）。小于 12 个月大的婴儿发病率下降幅度最大，为 75.3%。未接种疫苗的儿童也出现了明显下降。仅接种一剂疫苗后，疫苗对住院的有效率为 86.0%（95%CI，77.7-91.3）。自疫苗推出以来，绝大多数因轮状病毒住院的儿童（每个季节的比例从 91.8%到 100%不等）都没有接种任何轮状病毒疫苗系列。
