Kocsis J H, Sutton B M, Frances A J
Department of Psychiatry, New York Hospital-Cornell, University Medical Center, NY 10021.
J Clin Psychiatry. 1991 Feb;52(2):56-9.
A long-term follow-up assessment was conducted in 25 chronically depressed patients who had participated in a 6-week trial of imipramine to determine if imipramine responders would sustain a more favorable long-term outcome than nonresponders or noncompleters. Imipramine responders tended to remain on imipramine treatment throughout the follow-up interval and had a significantly better outcome. Eighty-nine percent of the imipramine responders met the criteria for recovery at follow-up compared with 31% in the comparison groups. Imipramine responders also fared significantly better at follow-up on measures of depression, global severity of illness, and social/vocational functioning. The results supported a more favorable long-term outcome in chronic depression patients who had responded to imipramine and suggest that maintenance therapy may be indicated and effective for this disorder.
对25名患有慢性抑郁症的患者进行了长期随访评估，这些患者曾参加过为期6周的丙咪嗪试验，以确定丙咪嗪治疗有效的患者是否比治疗无效或未完成治疗的患者能维持更良好的长期疗效。丙咪嗪治疗有效的患者在整个随访期间倾向于持续接受丙咪嗪治疗，且预后明显更好。随访时，89%的丙咪嗪治疗有效患者达到康复标准，而对照组这一比例为31%。在抑郁、疾病总体严重程度及社会/职业功能等指标的随访评估中，丙咪嗪治疗有效的患者情况也明显更好。结果表明，对丙咪嗪有反应的慢性抑郁症患者有更良好的长期预后，提示维持治疗可能适用于该疾病且有效。
