Homann Arne, Seibel Jürgen
Department of Organic Chemistry, University of Würzburg, Am Hubland, 97074, Würzburg, Germany.
Nat Prod Rep. 2009 Dec;26(12):1555-71. doi: 10.1039/b909990p. Epub 2009 Oct 22.
The advancing field of glycomics is driven by the development of new analysis and synthesis techniques and novel strategies such as metabolic glyco-labeling. In this review we will present strategies for tailoring chemo-enzymatic glycosyltransfer reactions, screening methods such as carbohydrate-based micro-arrays, and metabolic glyco-engineering as a strategy to visualize biological recognition processes for the development of carbohydrate-based vaccines.
糖组学这一前沿领域是由新的分析与合成技术以及诸如代谢糖基标记等新策略的发展所推动的。在本综述中，我们将介绍用于定制化学酶促糖基转移反应的策略、诸如基于碳水化合物的微阵列等筛选方法，以及代谢糖基工程，这是一种用于可视化生物识别过程以开发基于碳水化合物的疫苗的策略。
