Department of Psychology, Temple University, 1701 North 13th Street, Philadelphia, PA 19122, USA.
Psychopharmacology (Berl). 2010 Feb;208(2):201-9. doi: 10.1007/s00213-009-1719-9. Epub 2009 Nov 21.
A rich literature suggests that both impulsiveness and drug-induced euphoria are risk factors for drug abuse. However, few studies have examined whether sensitivity to the euphoric effects of stimulants is related to attention lapses, a behavioral measure of inattention sometimes associated with impulsivity.
The aim of the study was to examine ratings of d-amphetamine drug liking among individuals with high, moderate, and low attention lapses.
Ninety-nine healthy volunteers were divided into three equal-sized groups based on their performance on a measure of lapses of attention. The groups, who exhibited low, medium, and high attention lapses (i.e., long reaction times) on a simple reaction time task, were compared on their subjective responses (i.e., ratings of liking and wanting more drug) after acute doses of d-amphetamine (0, 5, 10, and 20 mg).
Subjects who exhibited high lapses liked 20 mg d-amphetamine less than subjects who exhibited low lapses. These subjects also tended to report smaller increases in "wanting more drug" after d-amphetamine.
The findings suggest that participants who exhibit impaired attention may be less sensitive to stimulant-induced euphoria.
丰富的文献表明，冲动和药物引起的欣快感都是药物滥用的风险因素。然而，很少有研究调查过对兴奋剂欣快感的敏感性是否与注意力不集中有关，注意力不集中是一种与冲动有关的注意力不集中的行为测量。
本研究旨在研究注意力不集中程度较高、中、低的个体对安非他明药物的喜爱程度。
99 名健康志愿者根据他们在注意力不集中测量中的表现分为三组。在简单反应时间任务中表现出注意力不集中（即反应时间较长）的三组，即低、中、高注意力不集中组，比较了他们在急性安非他明（0、5、10 和 20mg）剂量后的主观反应（即对药物的喜爱和更多药物的渴望评分）。
表现出高度注意力不集中的受试者比表现出低度注意力不集中的受试者更喜欢 20mg 的安非他命。这些受试者在安非他明后也倾向于报告“想要更多药物”的增加幅度较小。
研究结果表明，注意力受损的参与者可能对兴奋剂引起的欣快感不那么敏感。
