Lanham S A, Roberts C, Hollingworth T, Sreekumar R, Elahi M M, Cagampang F R, Hanson M A, Oreffo R O C
Bone and Joint Research Group, Developmental Origins of Health and Disease Division, Institute of Developmental Sciences, University of Southampton School of Medicine, Southampton, SO16 6YD, UK.
Osteoporos Int. 2010 Oct;21(10):1703-14. doi: 10.1007/s00198-009-1118-4. Epub 2009 Nov 21.
Peak bone mass is believed to partly be programmed in utero. Mouse dams and offspring were given a high-fat diet and offspring studied as adults. Female offspring from high-fat dams exhibited altered trabecular structure indicative of in utero programming. In utero nutrition has consequences in later life.
Epidemiological studies suggest that skeletal growth is programmed during intrauterine and early postnatal life. We hypothesise that development of optimal peak bone mass has, in part, a foetal origin and investigated this using a mouse model of maternal dietary fat excess.
Offspring from mouse dams fed either standard chow (C) or lifetime high-fat diet (HF) were maintained on a HF diet to adulthood. Femur samples were taken at 30 weeks of age and bone structure, adiposity and strength analysed. Sample sizes were four to six for each sex and each diet group.
Offspring from HF-fed dams showed increased adiposity in the femur in comparison to offspring from C-fed dams. Female offspring from HF dams exhibited altered trabecular structure indicative of in utero programming.
A maternal HF diet during pregnancy increases bone marrow adiposity and alters bone structure in their offspring.
峰值骨量被认为部分是在子宫内编程的。给母鼠及其后代喂食高脂饮食，并在成年后对后代进行研究。来自高脂饮食母鼠的雌性后代表现出小梁结构改变，这表明子宫内编程的存在。子宫内营养状况会对后期生活产生影响。
流行病学研究表明，骨骼生长是在子宫内和出生后早期生活中编程的。我们假设最佳峰值骨量的发育部分源于胎儿期，并使用母体饮食脂肪过量的小鼠模型对此进行了研究。
将喂食标准饲料（C）或终生高脂饮食（HF）的母鼠所产的后代维持高脂饮食至成年。在30周龄时采集股骨样本，并分析骨结构、脂肪含量和强度。每个性别和每个饮食组的样本量为4至6只。
与喂食标准饲料母鼠的后代相比，喂食高脂饮食母鼠的后代股骨中的脂肪含量增加。来自高脂饮食母鼠的雌性后代表现出小梁结构改变，这表明子宫内编程的存在。
孕期母体高脂饮食会增加后代骨髓脂肪含量并改变其骨结构。
