Institute of Dental Research, 1st Faculty of Medicine and General Faculty Hospital, Charles University in Prague, 121 11, Prague, Czech Republic.
Folia Microbiol (Praha). 2009 Sep;54(5):429-35. doi: 10.1007/s12223-009-0060-3. Epub 2009 Nov 24.
The incidence of potential periodontal pathogens (Aggregatibacter actinomycetemcomitans, formerly Actinobacillus actinomycetemcomitans, Tannerella forsythia, Porphyromonas gingivalis, Prevotella nigrescens, Prevotella intermedia and Capnocytophaga ochracea) was monitored in patients with chronic periodontitis and in healthy control subjects. Two types of studies were carried out in which the composition of the bacterial communities in different niches of the same oral cavity ecosystem was investigated. Fluctuation or at least pronounced quantitative changes in the incidence of individual species in time were documented in the long-term study as well as after the local administration of antibacterial drug Chlo-Site or Metronidazole. Even within two weeks, a turnover of the monitored bacteria in separate niches of the oral biotope can be detected. A relatively high incidence of the tested periopathogens in the clinically healthy teeth of patients implies that even the "healthy" niches in the periodontal biotope function as a dynamic reservoir of periopathogenic microorganisms. This should be kept in mind when a local application of antibacterial compounds is used in the therapy of periodontal disease.
慢性牙周炎患者和健康对照者的潜在牙周病原菌（伴放线放线杆菌，以前称为放线杆菌 actinomycetemcomitans，福赛拟杆菌，牙龈卟啉单胞菌，黑普雷沃菌，中间普雷沃菌和噬二氧化碳噬纤维菌）的发生率进行了监测。进行了两种类型的研究，其中研究了同一口腔生态系统不同小生境中的细菌群落组成。在长期研究以及局部使用抗菌药物氯己定或甲硝唑后，记录了个别物种在时间上的波动或至少明显的定量变化。即使在两周内，也可以检测到口腔生物区系中不同小生境中监测细菌的更替。在患者临床健康牙齿中检测到的测试牙周病原体的相对高发率表明，即使牙周生物区系中的“健康”小生境也作为牙周病原微生物的动态储库发挥作用。在牙周病的治疗中局部应用抗菌化合物时，应牢记这一点。
