aspericins A-C，新型呋喃和吡喃衍生物的结构测定，来自海洋来源真菌 Rhizopus sp. 2-PDA-61，通过 1D 和 2D NMR 光谱。

Structural determination of aspericins A-C, new furan and pyran derivates from the marine-derived fungus Rhizopus sp. 2-PDA-61, by 1D and 2D NMR spectroscopy.

机构信息

Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao 266003, P. R. China.

出版信息

Magn Reson Chem. 2010 Feb;48(2):155-8. doi: 10.1002/mrc.2545.

DOI:10.1002/mrc.2545

PMID:19937604

Abstract

Three new furan and pyran derivatives named aspericins A-C (1-3), as well as a known asperic acid (4), have been isolated from the marine-derived fungus Rhizopus sp. 2-PDA-61. The complete (1)H and (13)C NMR assignments for the new compounds were carried out using (1)H, (13)C, DEPT, COSY, HMQC, HMBC, and NOESY NMR experiments. Compounds 1-3 were evaluated for their cytotoxic activities on P388, A549, HL-60, and BEL-7420 cell lines by the MTT and SRB methods.

摘要

从海洋来源真菌 Rhizopus sp. 2-PDA-61 中分离得到三种新的呋喃和吡喃衍生物，分别命名为aspericins A-C（1-3），以及一种已知的asperic acid（4）。使用 1H、13C、DEPT、COSY、HMQC、HMBC 和 NOESY NMR 实验对新化合物的完整 1H 和 13C NMR 分配进行了研究。通过 MTT 和 SRB 方法，评估了化合物 1-3 对 P388、A549、HL-60 和 BEL-7420 细胞系的细胞毒性活性。