HS071，一种来自链霉菌属HS-HY-071的新型呋喃型细胞毒性代谢产物。
HS071, a new furan-type cytotoxic metabolite from Streptomyces sp. HS-HY-071.
作者信息
Wang Jidong, Zhang Hui, Yang Xiaohu, Zhou Yue, Wang Haibin, Bai Hua
机构信息
Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou, Zhejiang, China.
出版信息
J Antibiot (Tokyo). 2008 Oct;61(10):623-6. doi: 10.1038/ja.2008.82.
PMID:19168976
Abstract
Investigation of the bioactive metabolites from the soil-derived actinomycete, Streptomyces sp. HS-HY-071, a new furan-type antibiotic, HS071 (1), was isolated. Its structure was established as methyl 4-hydroxymethyl-2-pentylfuran-3-carboxylate on the basis of extensive 1D and 2D NMR and MS spectral analysis. It exhibited in vitro activity against HCT-116 cell with an IC50 of 18.2 microg/ml.
摘要
对土壤来源的放线菌链霉菌属HS-HY-071产生的生物活性代谢产物进行了研究，分离得到了一种新的呋喃型抗生素HS071（1）。基于广泛的一维和二维核磁共振及质谱光谱分析，确定其结构为4-羟甲基-2-戊基呋喃-3-羧酸甲酯。它对HCT-116细胞具有体外活性，IC50为18.2微克/毫升。
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