来自海洋苔藓虫 Stolonica socialis 的细胞毒代谢产物 stolonoxides E 和 F。

Stolonoxides E and F, cytotoxic metabolites from the marine ascidian Stolonica socialis.

机构信息

Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770-Colmenar Viejo, Madrid, Spain.

出版信息

J Nat Prod. 2010 Jan;73(1):83-5. doi: 10.1021/np900700h.

DOI:10.1021/np900700h

PMID:20014800

Abstract

Two new members of the stolonoxide family, stolonoxides E (1) and F (2), were isolated from samples of the marine ascidian Stolonica socialis collected in Cádiz (Spain). Their structures were determined by a combination of techniques, including (+)-HRESIMS, 1D and 2D NMR spectroscopy, and comparison with published data for the structurally related stolonoxides A-D (3-6). Both compounds displayed cytotoxicity against a panel of three human tumor cell lines.

摘要

从在西班牙 Cadiz 采集的海洋苔藓虫 Stolonica socialis 样本中分离到两个新的 stolonoxide 家族成员，stolonoxides E（1）和 F（2）。通过组合技术，包括（+）-HRESIMS、1D 和 2D NMR 光谱以及与结构相关的 stolonoxides A-D（3-6）的文献数据比较，确定了它们的结构。这两种化合物均对三种人肿瘤细胞系表现出细胞毒性。