Skivka L M, Horbyk H V, Fedorchuk O H, Pozur V V
Tsitol Genet. 2009 Jul-Aug;43(4):71-82.
Tumour-associated macrophages (TAM) make about 80% a total stromal leucocytes in solid tumours. Phenotypic and functional plasticity of this cell population causes its dual effect on tumour grows. Exceptional role of TAM in tumour progression makes them an attractive targets for selective cancer therapy. In this review the main groups of TAM-oriented methods of cancer therapy directed on inhibition of tumour angiogenesis and reactivation of antitumour action of TAM are analysed.
肿瘤相关巨噬细胞（TAM）在实体瘤中占全部基质白细胞的约80%。该细胞群体的表型和功能可塑性导致其对肿瘤生长产生双重影响。TAM在肿瘤进展中的特殊作用使其成为选择性癌症治疗的有吸引力的靶点。在本综述中，分析了主要的以TAM为导向的癌症治疗方法组，这些方法旨在抑制肿瘤血管生成和重新激活TAM的抗肿瘤作用。
