Neri Dario, Bicknell Roy
Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich, Switzerland.
Nat Rev Cancer. 2005 Jun;5(6):436-46. doi: 10.1038/nrc1627.
It is now accepted that the growth of solid tumours is dependent on their capacity to acquire a blood supply, and much effort has been directed towards the development of agents (known as anti-angiogenics) that disrupt this process. More recently, it has become apparent that targeted destruction of the established tumour vasculature is another avenue for exciting therapeutic opportunities. In this article, we present evidence that vascular targeting is an effective antitumour strategy in animal models, describe strategies for identifying putative tumour vascular targets and discuss future prospects for vascular targeting in the clinic.
目前已公认实体瘤的生长依赖于其获取血液供应的能力，并且人们已付出诸多努力来研发能够干扰这一过程的药物（称为抗血管生成药物）。最近，越来越明显的是，对已建立的肿瘤血管系统进行靶向破坏是另一个充满令人兴奋的治疗机会的途径。在本文中，我们提供证据表明血管靶向在动物模型中是一种有效的抗肿瘤策略，描述识别假定肿瘤血管靶点的策略，并讨论血管靶向在临床中的未来前景。
