Lambert V, Cova L, Chevallier P, Mehrotra R, Trepo C
INSERM Unité 271, Lyon, France.
J Gen Virol. 1991 Feb;72 ( Pt 2):417-20. doi: 10.1099/0022-1317-72-2-417.
Wild duck populations were investigated over a 4 year period for duck hepatitis B virus (DHBV) infection and liver disease. It appeared that DHBV is endemic in wild migratory mallards from France and the U.S.A., although neither hepatocellular carcinoma nor viral DNA integration could be detected in liver samples examined. The follow up of natural infection indicated that wild mallards developed significantly higher serum titres to DHBV DNA than Pekin ducks. The results of experimental transmission demonstrated that such differences in viraemia were not related to the breed of ducks but to the virus isolate, since the wild mallard-isolated DHBV (DHBV WM) induced significantly higher viraemia in both mallard and Pekin ducklings compared to the domestic Pekin DHBV (DHBVP) isolate. The naturally infected mallard and Pekin ducks had only minor histological lesions of the liver compared with experimentally infected birds. There was no correlation between the intensity of viraemia and the severity of liver lesions, suggesting that as for mammalian hepadnaviruses the hepatic injury in DHBV-infected ducks is probably immunologically mediated.
在4年时间里对野鸭种群进行了调查，以研究鸭乙型肝炎病毒（DHBV）感染和肝脏疾病。结果显示，DHBV在来自法国和美国的野生迁徙绿头鸭中呈地方性流行，尽管在所检测的肝脏样本中未检测到肝细胞癌和病毒DNA整合。自然感染的随访表明，野生绿头鸭产生的针对DHBV DNA的血清滴度明显高于北京鸭。实验性传播的结果表明，这种病毒血症的差异与鸭的品种无关，而是与病毒分离株有关，因为与家鸭北京鸭分离的DHBV（DHBVP）相比，从野生绿头鸭分离的DHBV（DHBV WM）在绿头鸭和北京鸭雏鸭中均诱导出明显更高的病毒血症。与实验感染的鸟类相比，自然感染的绿头鸭和北京鸭肝脏仅有轻微的组织学病变。病毒血症的强度与肝脏病变的严重程度之间没有相关性，这表明与哺乳动物嗜肝DNA病毒一样，DHBV感染鸭的肝损伤可能是由免疫介导的。
