Instituto de Química Médica (CSIC), C/Juan de la Cierva, 3, 28006-Madrid, Spain.
J Org Chem. 2009 Dec 18;74(24):9573-5. doi: 10.1021/jo902235h.
The NHC-catalyzed conjugate hydroacylation of 1,4-naphthoquinones allows for the synthesis of monoacylated 1,4-dihydroxynaphthalene derivatives. These targets, difficult to prepare selectively by standard protocols, represent important intermediates in the elaboration of highly substituted 1,4-naphthoquinone derivatives, which constitute relevant pharmaceutical scaffolds. High regioselectivity has been observed in the hydroacylation reaction when starting from nonsymmetrical quinones.
NHC 催化的 1,4-萘醌的共轭氢酰化反应允许合成单酰化的 1,4-二羟基萘衍生物。这些目标物很难通过标准协议选择性地制备，它们是高度取代的 1,4-萘醌衍生物的重要中间体，这些衍生物构成了相关的药物支架。当从不对称的醌开始时，在氢酰化反应中观察到了高区域选择性。
