直接、高效的 N-杂环卡宾催化醛的羟甲基化反应。
Direct and efficient N-heterocyclic carbene-catalyzed hydroxymethylation of aldehydes.
机构信息
Organisch-Chemisches Institut der Westfälischen Wilhelms-Universität Münster, Corrensstraße 40, 48149 Münster, Germany.
出版信息
Chem Commun (Camb). 2011 Jan 7;47(1):573-5. doi: 10.1039/c0cc02416c. Epub 2010 Nov 1.
PMID:21038072
Abstract
The N-heterocyclic carbene-catalyzed coupling of several aldehydes with paraformaldehyde is reported, directly providing the corresponding valuable hydroxymethyl ketones. Results of first mechanistic experiments for this remarkably selective transformation are also provided.
摘要
报道了 N-杂环卡宾催化多种醛与多聚甲醛的偶联反应，可直接得到相应的有价值的羟甲基酮。还提供了对此高度选择性转化的首次机理实验结果。
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