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Isolation and sequence of partial cDNA clones of human L1: homology of human and rodent L1 in the cytoplasmic region.

作者信息

Harper J R, Prince J T, Healy P A, Stuart J K, Nauman S J, Stallcup W B

机构信息

La Jolla Cancer Research Foundation, California.

出版信息

J Neurochem. 1991 Mar;56(3):797-804. doi: 10.1111/j.1471-4159.1991.tb01994.x.

DOI:10.1111/j.1471-4159.1991.tb01994.x
PMID:1993895
Abstract

We have isolated cDNA clones coding for the human homologue of the neuronal cell adhesion molecule L1. The nucleotide sequence of the cDNA clones and the deduced primary amino acid sequence of the carboxy terminal portion of the human L1 are homologous to the corresponding sequences of mouse L1 and rat NILE glycoprotein, with an especially high sequences identity in the cytoplasmic regions of the proteins. There is also protein sequence homology with the cytoplasmic region of the Drosophila cell adhesion molecule, neuroglian. The conservation of the cytoplasmic domain argues for an important functional role for this portion of the molecule.

摘要

相似文献

1
Isolation and sequence of partial cDNA clones of human L1: homology of human and rodent L1 in the cytoplasmic region.
J Neurochem. 1991 Mar;56(3):797-804. doi: 10.1111/j.1471-4159.1991.tb01994.x.
2
Drosophila neuroglian: a member of the immunoglobulin superfamily with extensive homology to the vertebrate neural adhesion molecule L1.果蝇神经胶质蛋白：免疫球蛋白超家族的一员，与脊椎动物神经黏附分子L1具有广泛的同源性。
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Structural features of a close homologue of L1 (CHL1) in the mouse: a new member of the L1 family of neural recognition molecules.小鼠中L1紧密同源物（CHL1）的结构特征：神经识别分子L1家族的一个新成员。
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Molecular cloning of cDNA encoding the rat neural cell adhesion molecule L1. Two L1 isoforms in the cytoplasmic region are produced by differential splicing.编码大鼠神经细胞黏附分子L1的cDNA的分子克隆。细胞质区域中的两种L1同工型是通过差异剪接产生的。
FEBS Lett. 1991 Sep 2;289(1):91-5. doi: 10.1016/0014-5793(91)80915-p.
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Characterization of cDNA clones defining variant forms of human neural cell adhesion molecule N-CAM.定义人神经细胞黏附分子N-CAM变异形式的cDNA克隆的特性分析
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Structure of a new nervous system glycoprotein, Nr-CAM, and its relationship to subgroups of neural cell adhesion molecules.一种新型神经糖蛋白Nr-CAM的结构及其与神经细胞黏附分子亚群的关系。
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Biochem Biophys Res Commun. 1991 Jul 31;178(2):444-52. doi: 10.1016/0006-291x(91)90127-s.

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