CECAV, Department of Veterinary Sciences, Universidade de Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal.
Res Vet Sci. 2010 Jun;88(3):441-5. doi: 10.1016/j.rvsc.2009.10.009. Epub 2009 Nov 25.
Immunohistochemical detection of Cyclooxygenase (Cox)-1 and -2 enzymes in canine mammary tumours (CMT) has recently been described. However, the prognostic value of their expression needs to be established. The aim of this study was to investigate Cox (-1 and -2) prognostic value in malignant CMT by evaluating its correlation with clinicopathological parameters (tumour size, histological type, necrosis, lymph node metastasis) and with Disease Free Survival (DFS) and Overall Survival (OS). Twenty seven female dogs with malignant tumours were included. Cox-2 expression was associated with lymph node metastasis at surgery time, development of distant metastasis during follow-up (p=0.038), DFS (p=0.03) and OS (p=0.04). Multivariate survival analysis showed that Cox-2 did not retain its significance as an independent prognostic factor. For Cox-1 expression, no statistically significant association was observed. Present study suggests the usefulness of testing Cox-2 specific inhibitors as part of an adjuvant therapy in female dogs with malignant mammary neoplasias.
免疫组织化学检测犬乳腺肿瘤（CMT）中的环氧化酶（Cox）-1 和 -2 酶最近已经被描述。然而，其表达的预后价值尚待确定。本研究的目的是通过评估 Cox（-1 和 -2）与临床病理参数（肿瘤大小、组织学类型、坏死、淋巴结转移）以及无病生存（DFS）和总生存（OS）的相关性，来研究 Cox（-1 和 -2）在恶性 CMT 中的预后价值。本研究共纳入 27 只患有恶性肿瘤的雌性犬。Cox-2 表达与手术时的淋巴结转移、随访期间远处转移的发展（p=0.038）、DFS（p=0.03）和 OS（p=0.04）相关。多变量生存分析表明，Cox-2 作为独立预后因素的意义不再显著。对于 Cox-1 表达，未观察到统计学显著相关性。本研究表明，在患有恶性乳腺肿瘤的雌性犬中，测试 Cox-2 特异性抑制剂作为辅助治疗的一部分是有用的。
