Karbowska Aleksandra, Boratyńska Maria, Klinger Marian
Klinika Nefrologii i Medycyny Transplantacyjnej we Wrocławiu, 50-417 Wrocław.
Postepy Hig Med Dosw (Online). 2009 Oct 23;63:485-91.
Cardiovascular diseases are currently the most frequent cause of death in Poland and their incidence continually rises. This is related to the high incidence of obesity associated with insulin resistance, which is present in type 2 diabetes mellitus. Adipose tissue produces multiple cytokines(TNF-alpha, IL-6, PAI-1, CRP, angiotensinogen, leptin, adiponectin, visfatin, apelin, resistin)which decrease insulin sensitivity and induce inflammatory processes, endothelial dysfunction,and atherosclerosis. This article presents the link between obesity, insulin resistance, and type 2 diabetes mellitus according to studies conducted in vitro and in animal models. In human studies, the influence of resistin on the development of insulin resistance is controversial. The article underlines the role of resisitin in the development of inflammatory processes and endothelial dysfunction in humans. In clinical studies, resistin was shown to be a predictive factor of coronary artery disease and mortality connected with cardiovascular diseases.
心血管疾病目前是波兰最常见的死因，且其发病率持续上升。这与2型糖尿病中存在的与胰岛素抵抗相关的高肥胖发生率有关。脂肪组织会产生多种细胞因子（肿瘤坏死因子-α、白细胞介素-6、纤溶酶原激活物抑制剂-1、C反应蛋白、血管紧张素原、瘦素、脂联素、内脂素、Apelin、抵抗素），这些细胞因子会降低胰岛素敏感性，并引发炎症过程、内皮功能障碍和动脉粥样硬化。本文根据体外和动物模型研究，阐述了肥胖、胰岛素抵抗与2型糖尿病之间的联系。在人体研究中，抵抗素对胰岛素抵抗发展的影响存在争议。本文强调了抵抗素在人类炎症过程和内皮功能障碍发展中的作用。在临床研究中，抵抗素被证明是冠状动脉疾病和心血管疾病相关死亡率的一个预测因素。
