Zulet Ma A, Puchau B, Navarro C, Martí A, Martínez J A
Departamento de Ciencias de la Alimentación, Fisiología y Toxicología, Universidad de Navarra, Pamplona, España.
Nutr Hosp. 2007 Sep-Oct;22(5):511-27.
[corrected] of this article is to review biomarkers that have been suggested in recent years as the link between inflammation, obesity and associated co-morbidities, as well as some questions that yet remain unclear. Increasing evidence indicates the important role of inflammation in the etiology of major public health problems. In the last years, several studies have proposed that obesity might be a inflammatory disorder. In addition, oxidative stress has been suggested as a potential inductor of inflammatory status and susceptibility to obesity and related disorders. Several biomarkers are being suggested as the link between obesity, insulin resistance, cardiovascular disease and metabolic syndrome, such as tumor necrosis factor alfa, interleukin-6 and -18, angiotensinogen, transforming grow factor beta, plasminogen activator inhibitor-1, leptin, resistin, C-reactive protein, serum amyloid A, sialic acid, fibrinogen, markers of endothelial dysfunction (von Willebrand factor, ICAMs, VCAMs), complement factor 3, haptoglobin, Zinc-alpha2-glycoprotein, eotaxin, visfatin, apelin, alpha1-antitrypsin, vaspin, omentin, retinol binding protein 4, ceruloplasmin, adiponectin and desnutrin. Some of this biomarkers are good predictors of cardiovascular risk (plasminogen activator inhibitor-1, sialic acid, fribrinogen, complement factor 3, C-reactive protein), adiposity (leptin, visfatin, resistin, haptoglobin) and/or insulin resistance (sialic acid, C-reactive protein, plasminogen activator inhibitor-1, von Willebrand factor). However, it is currently unclear the role of many of them concerning inflammatory processes in humans, as well as the factors involved in their regulation.
本文的[校正内容]是回顾近年来被认为是炎症、肥胖及相关合并症之间联系的生物标志物，以及一些仍不清楚的问题。越来越多的证据表明炎症在主要公共卫生问题的病因中起重要作用。在过去几年中，多项研究提出肥胖可能是一种炎症性疾病。此外，氧化应激被认为是炎症状态以及肥胖和相关疾病易感性的潜在诱导因素。几种生物标志物被认为是肥胖、胰岛素抵抗、心血管疾病和代谢综合征之间的联系，如肿瘤坏死因子α、白细胞介素-6和-18、血管紧张素原、转化生长因子β、纤溶酶原激活物抑制剂-1、瘦素、抵抗素、C反应蛋白、血清淀粉样蛋白A、唾液酸、纤维蛋白原、内皮功能障碍标志物（血管性血友病因子、细胞间黏附分子、血管细胞黏附分子）、补体因子3、触珠蛋白、锌-α2-糖蛋白、嗜酸性粒细胞趋化因子、内脏脂肪素、脂联素、α1-抗胰蛋白酶、内脏丝氨酸蛋白酶抑制剂、网膜素、视黄醇结合蛋白4、铜蓝蛋白、脂联素和去营养蛋白。其中一些生物标志物是心血管风险（纤溶酶原激活物抑制剂-1、唾液酸、纤维蛋白原、补体因子3、C反应蛋白）、肥胖（瘦素、内脏脂肪素、抵抗素、触珠蛋白）和/或胰岛素抵抗（唾液酸、C反应蛋白、纤溶酶原激活物抑制剂-1、血管性血友病因子）的良好预测指标。然而，目前尚不清楚它们中的许多在人类炎症过程中的作用，以及参与其调节的因素。
