Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
J Cell Physiol. 2019 Dec;234(12):21758-21769. doi: 10.1002/jcp.28913. Epub 2019 Jun 11.
Diabetes mellitus is a metabolic and chronic disorder, which is very common all over the world. Many genetic and nongenetic factors are involved in the development of type 2 diabetes mellitus (T2DM). Meanwhile, the resistin gene is an important candidate in the pathogenesis of this complex condition. High levels of transcription of the resistin gene are associated with inflammation, insulin resistance, initiation and development of T2DM and atherosclerosis progression through induction of secretion of bioactive materials from adipocytes. Releasing adipose tissue-derived inflammatory cytokines is associated with inflammatory processes activation, which causes inhibition of insulin action via interference with insulin signaling, such that these disorders can contribute to insulin resistance. With the direct effect of resistin and other inflammatory mediators on vascular endothelial cells and arterial walls, the expression of cell adhesion molecules is increased. This process can lead to atherosclerosis and will result in coronary artery disease (CAD). In this review, we will explore the effects of resistin on inflammation and insulin resistance that may lead to type 2 diabetes and CAD.
糖尿病是一种代谢和慢性疾病，在全球范围内非常普遍。许多遗传和非遗传因素参与了 2 型糖尿病（T2DM）的发生。同时，抵抗素基因是这种复杂疾病发病机制中的一个重要候选基因。抵抗素基因转录水平升高与炎症、胰岛素抵抗、T2DM 的发生和发展以及动脉粥样硬化进展有关，其通过诱导脂肪细胞分泌生物活性物质来实现。脂肪组织来源的炎性细胞因子的释放与炎症过程的激活有关，通过干扰胰岛素信号，导致胰岛素作用受到抑制，从而导致胰岛素抵抗。抵抗素和其他炎症介质对血管内皮细胞和动脉壁的直接作用会导致细胞黏附分子的表达增加。这个过程可能导致动脉粥样硬化，并导致冠心病（CAD）。在这篇综述中，我们将探讨抵抗素对炎症和胰岛素抵抗的影响，这些影响可能导致 2 型糖尿病和 CAD。
