Ichimura Ryohei, Shibutani Makoto, Mizukami Sayaka, Suzuki Terumasa, Shimada Yuko, Mitsumori Kunitoshi
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.
J Vet Med Sci. 2010 Feb;72(2):229-34. doi: 10.1292/jvms.09-0235. Epub 2009 Nov 25.
We report a rare case of benign sex cord-stromal tumor consisted largely of luteoma with minor portion of Sertoli cell tumor located at the position of the left ovary excision in an 11-year-old ovariectomized bitch. Granulosa cell component was lacking, and both luteal and Sertoli cell portions were entirely positive for inhibin alpha and neuron-specific enolase, whereas luteoma portion alone was positive for Wilms' tumor-1 (WT1), immunohistochemically. The results suggest that this tumor is a possible complication of incomplete ovarian excision at the time of ovariectomy and consisted of uncommon hybrid of luteal and Sertoli cells to be diagnosed as an unclassified sex cord-stromal tumor if applied in human cases. WT1-expression pattern suggested the signature of the difference in the phenotype of these cell types.
我们报告了一例罕见的良性性索间质肿瘤，主要由黄体瘤组成，在左侧卵巢切除部位有一小部分支持细胞瘤，该病例发生在一只11岁已切除卵巢的母犬身上。缺乏颗粒细胞成分，黄体细胞和支持细胞部分对抑制素α和神经元特异性烯醇化酶均呈完全阳性，而仅黄体瘤部分对威尔姆斯瘤-1（WT1）呈阳性，免疫组化结果如此。结果表明，该肿瘤可能是卵巢切除时卵巢切除不完全的并发症，由黄体细胞和支持细胞的罕见混合组成，如果应用于人类病例，可诊断为未分类的性索间质肿瘤。WT1表达模式提示了这些细胞类型表型差异的特征。
