Department of Medicine, Division of Allergic Diseases, Mayo Clinic and Foundation, Rochester, Minn., USA.
Int Arch Allergy Immunol. 2010;152(1):81-6. doi: 10.1159/000260088. Epub 2009 Nov 24.
Although common variable immunodeficiency (CVID) is associated with sinopulmonary disease, there are no previous systematic evaluations comparing computed tomographic (CT) sinus imaging with immunoglobulin measurements in patients with this condition.
We performed a retrospective review by a blinded observer using the Lund-Mackay numerical scoring scale as well as a visual scale for remodeling changes in the paranasal sinus bone on CT scans in CVID patients.
The sinus CT scans of 19 subjects (9 males, 10 females; median age at diagnosis 34 years) are described. There was an inverse relationship between serum IgM and sinus mucosal thickening as described by the Lund-Mackay scale (R = -0.6398; p = 0.0032). Osteitis of the paranasal sinus bone was almost exclusively found in patients with a reduced serum IgM level of less than 25 mg/dl (p = 0.0074).
This is the first study to show that sinus mucosal thickening on CT in patients with CVID is inversely related to serum IgM levels.
虽然普通变异性免疫缺陷（CVID）与鼻肺疾病有关，但以前没有系统评估比较 CVID 患者的鼻窦 CT 成像与免疫球蛋白测量。
我们通过盲法观察者进行了回顾性研究，使用 Lund-Mackay 数值评分量表以及鼻窦骨重塑改变的视觉量表对 CVID 患者的鼻窦 CT 扫描进行评估。
描述了 19 名受试者（9 名男性，10 名女性；诊断时的中位年龄为 34 岁）的鼻窦 CT 扫描结果。血清 IgM 与 Lund-Mackay 量表描述的鼻窦黏膜增厚呈负相关（R = -0.6398；p = 0.0032）。副鼻窦骨炎几乎仅见于血清 IgM 水平低于 25mg/dl 的患者（p = 0.0074）。
这是第一项表明 CVID 患者 CT 上鼻窦黏膜增厚与血清 IgM 水平呈负相关的研究。
