Toyota Josui Mental Clinic, 86-2 Minamidaira, Josui, Toyota, Aichi 470-0343, Japan.
Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, 7-430 Morioka, Obu, Aichi 474-8511, Japan.
Biomed Res Int. 2018 Jun 12;2018:4096845. doi: 10.1155/2018/4096845. eCollection 2018.
The aims of this study were to determine the prevalence of MRI abnormalities which were suspected as sinusitis in community-dwelling middle-aged and elderly Japanese and to identify risk factors for the MRI abnormality. Brain magnetic resonance imaging (MRI) data from the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA) were used for the analysis. Among the 2330 subjects in the NILS-LSA, 1933 participants were categorized as having no MRI abnormality or MRI abnormality using the Lund-Mackay (LM) score. The mean LM score of the participants was 0.88±1.92, and 144 (7.4%) participants had MRI abnormalities which were suspected as sinusitis when it was classified as an LM score greater than or equal to 4. The prevalence of MRI abnormality was significantly higher in participants of older age and the male sex, in participants with obesity, hypertension, bronchial asthma, chronic bronchitis, gout, or hyperuricemia and in ex- or current smokers. A multivariate logistic regression revealed that older age (odds ratio [OR] = 1.17), obesity (OR = 1.54), a smoking habit (OR = 1.71), history of asthma (OR = 3.77), and chronic bronchitis (OR = 2.66) were significant risk factors for MRI abnormality.
本研究旨在确定社区居住的中老年日本人疑似鼻窦炎的 MRI 异常的流行情况,并确定 MRI 异常的危险因素。本研究使用了日本国立长寿科学研究所(National Institute for Longevity Sciences)纵向老龄化研究(Longitudinal Study of Aging,NILS-LSA)的脑磁共振成像(MRI)数据。在 NILS-LSA 的 2330 名受试者中,有 1933 名受试者根据 Lund-Mackay(LM)评分被归类为无 MRI 异常或 MRI 异常。参与者的平均 LM 评分为 0.88±1.92,144 名(7.4%)参与者的 LM 评分大于或等于 4,被怀疑患有鼻窦炎的 MRI 异常。MRI 异常的患病率在年龄较大和男性、肥胖、高血压、支气管哮喘、慢性支气管炎、痛风或高尿酸血症以及既往或现在吸烟者中显著更高。多变量逻辑回归显示,年龄较大(比值比[OR] = 1.17)、肥胖(OR = 1.54)、吸烟习惯(OR = 1.71)、哮喘史(OR = 3.77)和慢性支气管炎(OR = 2.66)是 MRI 异常的显著危险因素。