设计材料以引导干细胞命运。
Designing materials to direct stem-cell fate.
机构信息
Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.
出版信息
Nature. 2009 Nov 26;462(7272):433-41. doi: 10.1038/nature08602.
Abstract
Proper tissue function and regeneration rely on robust spatial and temporal control of biophysical and biochemical microenvironmental cues through mechanisms that remain poorly understood. Biomaterials are rapidly being developed to display and deliver stem-cell-regulatory signals in a precise and near-physiological fashion, and serve as powerful artificial microenvironments in which to study and instruct stem-cell fate both in culture and in vivo. Further synergism of cell biological and biomaterials technologies promises to have a profound impact on stem-cell biology and provide insights that will advance stem-cell-based clinical approaches to tissue regeneration.
摘要
适当的组织功能和再生依赖于通过机制对生物物理和生化微环境线索进行强大的时空控制，这些机制仍知之甚少。生物材料正在迅速被开发出来，以精确和近乎生理的方式展示和传递干细胞调节信号，并作为强大的人工微环境，用于在培养物和体内研究和指导干细胞命运。细胞生物学和生物材料技术的进一步协同作用有望对干细胞生物学产生深远影响，并提供见解，从而推进基于干细胞的组织再生临床方法。
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