Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, PR China.
Phytother Res. 2010 May;24(5):769-74. doi: 10.1002/ptr.3047.
Danshen is the dried root and rhizome of the Chinese medicinal plant Salvia miltiorrhiza Bunge (Labiatae), which has been used to treat hypertension and myocardial infarction. One of its water-soluble active components is magnesium tanshinoate B (MTB). The present study examined and compared the cardiovascular effects of the water-soluble extract of danshen (SME) and its MTB-enriched form (containing 70% of MTB (MTB70)). Anaesthetized rats were infused intravenously with saline or phenylephrine to achieve a normal or elevated blood pressure, respectively. Different doses of SME, MTB70 or vehicle were then injected intravenously and their effect on blood pressure was monitored. The results indicate that SME and MTB70 reduce blood pressure dose-dependently. Independently of the initial blood pressure, SME caused a smaller reduction in blood pressure than MTB70. In rats infused with phenylephrine, MTB70 caused greater decreases in blood pressure than in rats infused with saline, while the responses to SME did not differ between the two groups. From these findings, it appears that MTB is one of the major components responsible for the cardiovascular effects of danshen, and that the beneficial cardiovascular effect of the extract is more prominent under conditions of elevated blood pressure.
丹参是唇形科植物丹参（Salvia miltiorrhiza Bunge）的干燥根和根茎，用于治疗高血压和心肌梗死。其一种水溶性活性成分是镁丹参酮 B（MTB）。本研究考察和比较了丹参水溶性提取物（SME）及其富含 MTB 的形式（含有 70%的 MTB（MTB70））的心血管作用。麻醉大鼠分别静脉输注生理盐水或去甲肾上腺素，以分别达到正常或升高的血压。然后静脉注射不同剂量的 SME、MTB70 或载体，并监测其对血压的影响。结果表明，SME 和 MTB70 呈剂量依赖性降低血压。与初始血压无关，SME 引起的血压降低小于 MTB70。在输注去甲肾上腺素的大鼠中，MTB70 引起的血压下降大于输注生理盐水的大鼠，而 SME 的反应在两组之间没有差异。从这些发现来看，MTB 是丹参心血管作用的主要成分之一，并且在血压升高的情况下，提取物的有益心血管作用更为突出。
