交替环肽，一种源自海洋真菌链格孢属SF-5016的环状缩肽。

Alternaramide, a cyclic depsipeptide from the marine-derived fungus Alternaria sp. SF-5016.

作者信息

Kim Min-Young, Sohn Jae Hak, Ahn Jong Seog, Oh Hyuncheol

机构信息

College of Medical and Life Sciences, Silla University, Busan 617-736, Korea.

出版信息

J Nat Prod. 2009 Nov;72(11):2065-8. doi: 10.1021/np900464p.

DOI:10.1021/np900464p

PMID:19943624

Abstract

Alternaramide (1), a cyclic pentadepsipeptide, has been isolated from an EtOAc extract of the marine-derived fungus Alternaria sp. SF-5016 by various chromatographic methods. The structure of 1 was mainly determined by analysis of the NMR spectroscopic data, along with chemical methods such as Marfey's and Mosher's methods. Alternaramide (1) showed weak antibiotic activity against Bacillus subtilis and Staphylococcus aureus.

摘要

交替环肽（1）是一种环状五肽缩酚酸肽，通过多种色谱方法从海洋来源的链格孢属真菌SF-5016的乙酸乙酯提取物中分离得到。化合物1的结构主要通过核磁共振光谱数据分析以及化学方法如马尔费方法和莫舍尔方法确定。交替环肽（1）对枯草芽孢杆菌和金黄色葡萄球菌显示出微弱的抗菌活性。