Wang Wenliang, Wang Yi, Tao Hongwen, Peng Xiaoping, Liu Peipei, Zhu Weiming
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, People's Republic of China.
J Nat Prod. 2009 Sep;72(9):1695-8. doi: 10.1021/np9002299.
In order to search for structurally novel and bioactive natural compounds from marine-derived fungi, a halotolerant fungal strain (THW-18) identified as Alternaria raphani was isolated from sediment collected in the Hongdao sea salt field. From the ethyl acetate extract of Alternaria raphani, three new cerebrosides, alternarosides A-C (1-3), and a new diketopiperazine alkaloid, alternarosin A (4), together with 15 known compounds were isolated and identified by spectroscopic and chemical methods, as well as X-ray crystal diffraction analysis. Compounds 1-4 showed weak antibacterial activity against Escherichia coli, Bacillus subtilis, and Candida albicans with MIC values ranging from 70 to 400 muM.
为了从海洋来源的真菌中寻找结构新颖且具有生物活性的天然化合物，从青岛红岛海盐场采集的沉积物中分离出一株耐盐真菌菌株（THW-18），鉴定为萝卜链格孢。通过光谱、化学方法以及X射线晶体衍射分析，从萝卜链格孢的乙酸乙酯提取物中分离并鉴定出3个新的脑苷脂类化合物链格孢苷A-C（1-3）、1个新的二酮哌嗪生物碱链格孢菌素A（4）以及15个已知化合物。化合物1-4对大肠杆菌、枯草芽孢杆菌和白色念珠菌显示出较弱的抗菌活性，其最低抑菌浓度（MIC）值范围为70至400 μM。
