Agrawal Shivankar, Acharya Debabrata, Adholeya Alok, Barrow Colin J, Deshmukh Sunil K
Biotechnology and Management of Bioresources Division, TERI-Deakin Nano Biotechnology Centre, Energy and Resources Institute, New Delhi, India.
Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC, Australia.
Front Pharmacol. 2017 Nov 21;8:828. doi: 10.3389/fphar.2017.00828. eCollection 2017.
Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospecting of marine microbes have achieved many remarkable milestones in pharmaceutics. Till date, more than 50% of drugs which are in clinical use belong to the nonribosomal peptide or mixed polyketide-nonribosomal peptide families of natural products isolated from marine bacteria, cyanobacteria and fungi. In recent years large numbers of nonribosomal have been discovered from marine microbes using multi-disciplinary approaches. The present review covers the NRPs discovered from marine microbes and their pharmacological potential along with role of genomics, proteomics and bioinformatics in discovery and development of nonribosomal peptides drugs.
海洋环境在很大程度上尚未被探索，它可能是用于治疗许多疾病（如疟疾、癌症、结核病、艾滋病等）的新分子的来源。海洋环境是获取具有药理活性的非核糖体肽（NRP）的未开发生物资源之一。海洋微生物的生物勘探在制药领域已经取得了许多显著的里程碑。迄今为止，超过50%的临床使用药物属于从海洋细菌、蓝细菌和真菌中分离出的天然产物的非核糖体肽或聚酮化合物 - 非核糖体肽混合家族。近年来，利用多学科方法从海洋微生物中发现了大量非核糖体肽。本综述涵盖了从海洋微生物中发现的非核糖体肽及其药理潜力，以及基因组学、蛋白质组学和生物信息学在非核糖体肽药物发现和开发中的作用。
