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高风险国家的髋部骨折发病率的地域差异延伸至北极地区:一项NOREPOS 研究。

Geographic variations in hip fracture incidence in a high-risk country stretching into the Arctic: a NOREPOS study.

机构信息

Department of Chronic Diseases and Ageing, Norwegian Institute of Public Health, Oslo, Norway.

Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, P.O. Box 1130, Blindern, N-0318, Oslo, Norway.

出版信息

Osteoporos Int. 2020 Jul;31(7):1323-1331. doi: 10.1007/s00198-020-05346-8. Epub 2020 Feb 24.

Abstract

UNLABELLED

There are geographic variations in hip fracture incidence rates across Norway, with a lower incidence in the coastal areas of the southwest and in the Arctic north, contrary to what may be expected with regard to vitamin D exposure from sunlight. The regional differences have become smaller in recent years.

INTRODUCTION

To investigate geographic variation in hip fracture incidence within Norway and regional differences in time trends.

METHODS

All hip fractures treated in Norwegian hospitals 2002-2013 were included, and demographic information was obtained from Statistics Norway. Age-standardized incidence rates were calculated separately for 19 counties. Incidence rate ratios with 95% confidence intervals for county differences and time trends were estimated using Poisson regression.

RESULTS

Age-standardized number of hip fractures per 10,000 person-years varied between counties from 69 to 84 in women and from 34 to 41 in men. The highest rates were observed in the southeastern capital city of Oslo, while rates were low in the four northernmost counties. There was an east-west gradient, with lower incidence in the coastal southwest compared with the southeast. Women showed a statistically significant decline during 2002-2013 in almost all counties (up to 31%). In men, only a few counties showed a decline. In both genders, hip fracture rates at age 80 in the combined five counties with the highest rates were significantly higher than in the combined five counties with the lowest rates across the period, although the trends converged over time.

CONCLUSIONS

In Norway, the hip fracture incidence was lower in the north compared with the south. In addition, we observed an east-west gradient with the highest incidence in the southeast and lower incidence in the coastal southwest. While there has been an overall declining trend in hip fracture incidence over time, regional differences are still apparent.

摘要

目的

调查挪威境内髋部骨折发病率的地域差异,以及各地区时间趋势的差异。

方法

纳入 2002-2013 年期间在挪威医院治疗的所有髋部骨折患者,并从挪威统计局获取人口统计学信息。为每个县分别计算年龄标准化发病率。使用泊松回归估计县差异和时间趋势的发病率比及其 95%置信区间。

结果

年龄标准化每 10000 人年髋部骨折人数在女性中各县之间差异为 69 至 84,在男性中为 34 至 41。最高发病率出现在东南部的首都奥斯陆,而在最北部的四个县发病率较低。存在一个从东到西的梯度,与东南部相比,西南部沿海地区的发病率较低。女性在 2002-2013 年期间,几乎所有县(最多 31%)的发病率均呈统计学显著下降。男性中,只有少数几个县的发病率下降。在两性中,年龄 80 岁时,五个发病率最高的县的髋部骨折率明显高于五个发病率最低的县,尽管趋势随时间而趋同。

结论

在挪威,与南部相比,北部的髋部骨折发病率较低。此外,我们观察到一个从东到西的梯度,东南部的发病率最高,西南部沿海地区的发病率较低。虽然髋部骨折发病率总体呈下降趋势,但仍存在明显的地域差异。

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