维持小鼠黑色素瘤生长的癌症干细胞并不罕见。

Cancer stem cells sustaining the growth of mouse melanoma are not rare.

机构信息

Department of Immunology, Cancer Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, 17 Pan Jia Yuan Nan Li, Chao Yang, Beijing, China.

出版信息

Cancer Lett. 2010 Jun 1;292(1):17-23. doi: 10.1016/j.canlet.2009.10.021. Epub 2009 Nov 26.

DOI:10.1016/j.canlet.2009.10.021

PMID:19944522

Abstract

Cancer stem cell (CSC) is generally believed to be a very small proportion of tumor cells capable of initiating and sustaining growth of the tumor. Its existence is usually demonstrated by xenotransplanting human cancer cells in immunodeficient mice. In this paper, we report that the growth of B16-F10 melanoma cells in syngeneic mice could be maintained by a relatively larger proportion (>10%) of tumor cells. The result of this study does not seem to support the current view that cancer stem cells (CSCs) responsible for the sustainable growth of tumor are rare.

摘要

癌症干细胞（CSC）通常被认为是一小部分能够启动和维持肿瘤生长的肿瘤细胞。其存在通常通过将人癌细胞异种移植到免疫缺陷小鼠中来证明。在本文中，我们报告称，在同基因小鼠中，B16-F10 黑色素瘤细胞的生长可以由相对较大比例（>10%）的肿瘤细胞维持。这一研究结果似乎不支持目前认为负责肿瘤持续生长的癌症干细胞（CSC）很少的观点。