Wessel J R, Yess N J
Food and Drug Administration, Office of Regulatory Affairs, Rockville, MD 20857.
Rev Environ Contam Toxicol. 1991;120:83-104. doi: 10.1007/978-1-4612-3080-9_2.
Interest in pesticide residues in foods has increased, and the issue of residues in imported foods has been raised as a potential public health problem. Three U.S. government agencies, EPA, FDA, and USDA, are responsible for regulating pesticides. EPA sets tolerances, and FDA and USDA enforce those tolerances. As part of its regulatory activities, FDA conducts a regulatory monitoring program that samples and analyzes each year approximately 20,000 food shipments, about 60% of which are imports. Samples of imported foods are collected at ports of entry, and are chosen on the basis of several factors rather than on a completely random basis. Raw agricultural products are emphasized. Most analyses are performed using MRMs, to make best use of FDA's resources. Using five MRMs, about half of the 300 pesticides with U.S. tolerances can be determined. Results from monitoring over the past several years have shown that nearly 60% of the imported foods sampled had no pesticide residues detected. Of those samples that were violative, 5% contained residues for which there was no U.S. tolerance, and less than 1% had over-tolerance residues. Examples are given of the various pesticide/commodity combinations that have been found to be violative. FDA is often criticized for the scope of its pesticide coverage, particularly with regard to imported foods. Some critics have promoted the idea of a 'circle of poison,' which is based on the premise that pesticides banned in the U.S. are exported and used on foods in foreign countries; then the food containing these residues is imported into the U.S. and consumed. However, FDA's testing of imported foods has shown that residues of EPA-banned pesticides are not occurring from currently purposeful uses. The violation rates for imports also have not been significantly different from those for domestic foods. This indicates that foreign producers, as well as domestic growers, generally use pesticides in a manner consistent with EPA requirements. FDA continues to broaden its information-gathering capabilities. As mandated by the PMIA of 1988, FDA will attempt to obtain pesticide use information from countries that are major food exporters to the United States. An improved data management system will also be in place, and a long-range analytical method development plan instituted. Several international organizations address the issue of pesticide residues in foods. Attempts at harmonization of national tolerances for pesticide residues have not been successful, i.e., a number of individual nations have not accepted Codex MRLs.(ABSTRACT TRUNCATED AT 400 WORDS)
人们对食品中的农药残留愈发关注,进口食品中的残留问题也已作为一个潜在的公共卫生问题被提了出来。美国三个政府机构,即美国环境保护局(EPA)、美国食品药品监督管理局(FDA)和美国农业部(USDA)负责监管农药。EPA设定容忍度,FDA和USDA执行这些容忍度。作为其监管活动的一部分,FDA开展了一项监管监测计划,每年对约20000批食品货物进行抽样和分析,其中约60%是进口食品。进口食品样本在入境口岸采集,其选择基于多个因素而非完全随机抽取。重点是未加工的农产品。大多数分析采用多反应监测(MRMs),以便最有效地利用FDA的资源。使用五种多反应监测方法,可以测定约300种有美国容忍度的农药中的一半。过去几年的监测结果表明,近60%的抽样进口食品未检测出农药残留。在那些违规样本中,5%含有美国没有容忍度的残留,不到1%的残留超标。文中给出了已发现违规的各种农药/商品组合的例子。FDA常因其农药覆盖范围,尤其是进口食品方面,受到批评。一些批评者提出了“毒圈”的概念,其前提是在美国被禁用的农药被出口并用于国外的食品;然后含有这些残留的食品被进口到美国并被食用。然而,FDA对进口食品的检测表明,EPA禁用农药的残留并非来自当前的故意使用。进口食品的违规率与国内食品的违规率也没有显著差异。这表明外国生产商以及国内种植者通常以符合EPA要求的方式使用农药。FDA继续扩大其信息收集能力。根据1988年《农药监测改进法案》(PMIA)的要求,FDA将试图从向美国大量出口食品的国家获取农药使用信息。还将建立一个改进的数据管理系统,并制定一个长期的分析方法开发计划。几个国际组织也在处理食品中农药残留的问题。协调各国农药残留容忍度的尝试尚未成功,也就是说,一些国家并未接受食品法典最大残留限量(Codex MRLs)。(摘要截选至400字)