Department of Biotechnology, Daegu University, Kyoungsan, Kyoungbook 712-714, Republic of Korea.
Food Chem Toxicol. 2010 Feb;48(2):639-43. doi: 10.1016/j.fct.2009.11.045. Epub 2009 Nov 26.
This study was undertaken to evaluate the effect of essential oil from seeds of Zizyphus jujuba on TPA-induced skin inflammation in experimental mice. Exposure of TPA on the ear of the BALB/c mice caused a marked increase in both ear thickness and skin water content. The ear thickness was measured for TPA-induced ear was 0.54 mm, as compared to control (0.23 mm). Treatment with 1% and 10% of essential oil caused significant decrease in ear thicknesses which were measured to be 0.30 and 0.35 mm, as well as reduce the water content about 51% and 53% in the TPA-induced skin inflammation model, respectively. Furthermore, histological analysis clearly confirmed that Z. jujuba essential oil inhibited the inflammatory responses of skin inflammation in animal model. Therefore, our findings demonstrate that the essential oil of Z. jujuba seeds might accelerate the development of new drugs for various inflammatory diseases.
本研究旨在评估枣(Zizyphus jujuba)籽油对 TPA 诱导的实验性小鼠皮肤炎症的影响。TPA 暴露于 BALB/c 小鼠的耳朵上会导致耳朵厚度和皮肤水分含量的显著增加。TPA 诱导的耳朵厚度为 0.54 毫米，而对照(0.23 毫米)。1%和 10%的精油处理可显著降低耳厚度，分别测量为 0.30 和 0.35 毫米，并可降低 TPA 诱导的皮肤炎症模型中约 51%和 53%的水分含量。此外，组织学分析清楚地证实，枣籽油抑制了动物模型中皮肤炎症的炎症反应。因此，我们的研究结果表明，枣籽油可能会加速各种炎症性疾病新药的开发。
