Department of Gene Technology, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia.
Neurosci Lett. 2010 Jan 18;469(1):135-40. doi: 10.1016/j.neulet.2009.11.060. Epub 2009 Nov 26.
Ligands of NGF and GDNF families of neurotrophic factors have important functions in the development of the vertebrate peripheral nervous system (PNS). It has been established that they also play key roles in the regeneration of PNS. Expression patterns of NGF and GDNF family members and their receptors have mostly been analyzed during regeneration, and less during development of the PNS. We describe the expression of mRNAs encoding these neurotrophic factors and their receptors during development of rat sciatic nerve and in three modes of differentiation of cultured rat Schwann cells. Our results demonstrate specific expression patterns of NGF and GDNF family ligands and their receptors during differentiation of Schwann cells in vivo and in vitro.
神经营养因子 NGF 和 GDNF 家族的配体在脊椎动物周围神经系统（PNS）的发育中具有重要功能。已经证实，它们在 PNS 的再生中也起着关键作用。NGF 和 GDNF 家族成员及其受体的表达模式主要在 PNS 再生过程中进行了分析，而在 PNS 发育过程中则较少。我们描述了编码这些神经营养因子及其受体的 mRNA 在大鼠坐骨神经发育过程中的表达，以及在培养的大鼠许旺细胞的三种分化模式中的表达。我们的研究结果表明，在体内和体外许旺细胞的分化过程中，NGF 和 GDNF 家族配体及其受体具有特定的表达模式。
