Sauer Cary G, Kugathasan Subra
Department of Pediatrics, Emory University School of Medicine, Emory Children's Center, 2015 Uppergate Drive, Atlanta, GA 30322, USA.
Med Clin North Am. 2010 Jan;94(1):35-52. doi: 10.1016/j.mcna.2009.10.002.
Inflammatory bowel disease (IBD) includes Crohn disease and ulcerative colitis, and is often diagnosed in late childhood and early adulthood. What determines the age of onset remains unexplained. Early onset may represent the "pure" form of the disease process and hence may hold secrets of the initiating events of IBD pathogenesis. Clinical scientists continue to focus on pediatric IBD because it may shed light on the cause and prevention of this lifelong disease. Over the last decade, data in pediatric IBD studies have demonstrated many similarities and differences between pediatric and adult onset, which continue to add pieces to an increasingly complex IBD puzzle. The mechanism responsible for these similarities and differences remains unanswered. This article discusses clinically relevant epidemiology and treatment aspects of pediatric IBD, with special focus on similarities and differences in pediatric and adult IBD. Evidence-based treatment algorithms, with special focus on pediatric studies and care for children, are also highlighted.
炎症性肠病（IBD）包括克罗恩病和溃疡性结肠炎，常在儿童晚期和成年早期被诊断出来。发病年龄的决定因素尚不清楚。早发型可能代表疾病过程的“纯粹”形式，因此可能蕴含炎症性肠病发病机制起始事件的秘密。临床科学家持续关注儿童炎症性肠病，因为它可能有助于揭示这种终身疾病的病因及预防方法。在过去十年中，儿童炎症性肠病研究数据已表明儿童发病和成人发病之间存在许多异同，这继续为日益复杂的炎症性肠病难题增添线索。造成这些异同的机制仍未得到解答。本文讨论儿童炎症性肠病临床相关的流行病学和治疗方面，特别关注儿童和成人炎症性肠病的异同。还重点强调了基于证据的治疗算法，尤其关注儿童研究及儿童护理。
