Picco Michael F, Cangemi John R
Department of Medicine, Division of Gastroenterology, 4500 San Pablo Rd., Mayo Clinic, Jacksonville, FL 32224, USA.
Gastroenterol Clin North Am. 2009 Sep;38(3):447-62. doi: 10.1016/j.gtc.2009.06.006.
This article reviews the epidemiology, clinical manifestations, diagnosis, prognosis, and treatment of inflammatory bowel disease (IBD), which will grow in prevalence as the population ages. Prognosis of late-onset ulcerative colitis (UC) is generally similar to that of early-onset UC, whereas in Crohn disease it is probably better because of a tendency for colonic involvement. Disease complications are related more to the duration of the inflammatory bowel disease than the subject's current age. The diagnosis in elderly patients can be challenging due to the large number of conditions that mimic IBD on radiologic, endoscopic, and histologic testing. Distinguishing these conditions from IBD will significantly alter prognosis and treatment. Complications related to IBD and its treatment are common and must be recognized early to limit their impact in a vulnerable elderly population.
本文综述了炎症性肠病（IBD）的流行病学、临床表现、诊断、预后及治疗。随着人口老龄化，IBD的患病率将会上升。晚发型溃疡性结肠炎（UC）的预后通常与早发型UC相似，而在克罗恩病中，由于结肠受累的倾向，其预后可能更好。疾病并发症更多地与炎症性肠病的病程相关，而非患者的当前年龄。老年患者的诊断具有挑战性，因为在放射学、内镜及组织学检查中有大量疾病与IBD相似。将这些疾病与IBD区分开来将显著改变预后及治疗。与IBD及其治疗相关的并发症很常见，必须尽早识别，以限制其对脆弱老年人群的影响。
