Department of Pediatrics, Emory University School of Medicine, Emory Children's Center, 2015 Uppergate Drive, Atlanta, GA 30322, USA.
Gastroenterol Clin North Am. 2009 Dec;38(4):611-28. doi: 10.1016/j.gtc.2009.07.010.
Inflammatory bowel disease (IBD) includes Crohn disease and ulcerative colitis, and is often diagnosed in late childhood and early adulthood. What determines the age of onset remains unexplained. Early onset may represent the "pure" form of the disease process and hence may hold secrets of the initiating events of IBD pathogenesis. Clinical scientists continue to focus on pediatric IBD because it may shed light on the cause and prevention of this lifelong disease. Over the last decade, data in pediatric IBD studies have demonstrated many similarities and differences between pediatric and adult onset, which continue to add pieces to an increasingly complex IBD puzzle. The mechanism responsible for these similarities and differences remains unanswered. This article discusses clinically relevant epidemiology and treatment aspects of pediatric IBD, with special focus on similarities and differences in pediatric and adult IBD. Evidence-based treatment algorithms, with special focus on pediatric studies and care for children, are also highlighted.
炎症性肠病（IBD）包括克罗恩病和溃疡性结肠炎，通常在儿童晚期和成年早期诊断。发病年龄的决定因素仍不清楚。早期发病可能代表疾病过程的“纯”形式，因此可能揭示 IBD 发病机制的起始事件的秘密。临床科学家继续关注儿科 IBD，因为它可能为这种终身疾病的病因和预防提供线索。在过去的十年中，儿科 IBD 研究中的数据表明，儿科和成人发病之间存在许多相似之处和差异，这些相似之处和差异不断为日益复杂的 IBD 难题增添新的内容。导致这些相似和差异的机制尚未得到解答。本文讨论了儿科 IBD 的临床相关流行病学和治疗方面，特别关注儿科和成人 IBD 的相似和差异。还强调了基于证据的治疗算法，特别关注儿科研究和儿童护理。
