Section of Neonatal-Perinatal Medicine, Department of Pediatrics, The Children's Hospital, College of Medicine, The University of Oklahoma Health Sciences Center, 1200 Everett Drive, Oklahoma City, OK 73104-5047, USA.
Clin Perinatol. 2009 Dec;36(4):723-36, v. doi: 10.1016/j.clp.2009.07.015.
Little is known about the effect on clinically relevant outcomes of the complex hemodynamic changes occurring during adaptation to extrauterine life in preterm neonates, particularly in very low birth weight neonates. As cardiovascular adaptation in this extremely vulnerable patient population is complicated by immaturity of all organ systems, especially that of the cardiorespiratory, central nervous, and endocrine systems, maladaptation has been suspected, but not necessarily proven, to contribute to mortality and long-term morbidities. This article describes recent advances in the understanding of hemodynamic changes in very low birth weight neonates during postnatal transition, and reviews the complex and developmentally regulated interaction between systemic and cerebral hemodynamics and the effect of this interaction on clinically relevant outcomes.
对于早产儿适应宫外生活过程中发生的复杂血液动力学变化对临床相关结局的影响，人们知之甚少，特别是极低出生体重儿。由于所有器官系统，尤其是心肺、中枢神经和内分泌系统的不成熟，使这一极其脆弱的患者群体的心血管适应变得复杂，因此尽管尚未得到证实，但人们怀疑不适应会导致死亡率和长期发病率增加。本文描述了人们对极低出生体重儿出生后过渡期间血液动力学变化的理解的最新进展，并回顾了全身和大脑血液动力学之间复杂的、受发育调控的相互作用及其对临床相关结局的影响。
