Department of Neurology and Neurosurgery, School of Physical and Occupational Therapy, McGill University, 2300 Tupper Street, Montreal, Quebec, H3H 1P3, Canada.
Clin Perinatol. 2009 Dec;36(4):791-805, vi. doi: 10.1016/j.clp.2009.07.010.
Recent studies in survivors of extreme prematurity point to an increased prevalence of a previously underrecognized atypical social-behavioral profile strongly suggestive of an autism spectrum disorder. Prospective studies that incorporate early autism screening and autism diagnostic testing are needed to better delineate the sensitivity and specificity of early signs of autism in ex-premature children. Advances in neonatal MRI techniques capable of quantitative structural and functional measurements will also provide important insights into the effects of prematurity itself, and prematurity-related brain injury on the genesis of autism spectrum disorders in this population. Available evidence linking prematurity and autism spectrum disorders is reviewed in this article.
最近对极端早产儿幸存者的研究表明，一种以前未被认识到的非典型社会行为模式更为普遍，强烈提示存在自闭症谱系障碍。需要进行前瞻性研究，将早期自闭症筛查和自闭症诊断测试结合起来，以更好地区分早产儿早期自闭症迹象的敏感性和特异性。能够进行定量结构和功能测量的新生儿 MRI 技术的进步也将为早产儿本身以及与早产相关的脑损伤对该人群自闭症谱系障碍发生的影响提供重要的见解。本文综述了将早产儿与自闭症谱系障碍联系起来的现有证据。
