Department of Otolaryngology-Head and Neck Surgery, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Am J Otolaryngol. 2010 Jan-Feb;31(1):9-13. doi: 10.1016/j.amjoto.2008.08.013. Epub 2009 Mar 13.
The aim of this study was to investigate the preventive effect of mitomycin-C (MMC) on external auditory canal (EAC) fibrosis in an animal model.
This is a randomized, controlled animal study.
Sixteen guinea pigs were used for this study. After the skin of cartilaginous EAC was injured with an electrocautery, the cottonoid soaked in MMC solution with concentration of 0.4 mg/mL was topically applied for 5 minutes to the injured EAC in an MMC-treated group (n = 8). In addition, saline was applied in the control group (n = 8). At 4 weeks after injury, postsurgical changes of EAC were evaluated by histologic examination.
External auditory canal fibrosis was induced by injury with electrocautery. The MMC-treated group showed less degree of fibrosis without differences in epithelialization and inflammatory cell infiltration.
This study suggests that MMC can be helpful in preventing EAC fibrosis after injury.
本研究旨在探讨丝裂霉素 C（MMC）在动物模型中对外耳道（EAC）纤维化的预防作用。
这是一项随机对照动物研究。
本研究使用了 16 只豚鼠。用电烙术损伤软骨外耳道皮肤后，将浓度为 0.4mg/ml 的 MMC 溶液浸泡的棉片局部应用于 MMC 治疗组（n=8）的损伤 EAC 5 分钟。此外，对照组（n=8）应用生理盐水。损伤后 4 周，通过组织学检查评估 EAC 的术后变化。
电烙术损伤可引起外耳道纤维化。MMC 治疗组纤维化程度较轻，上皮化和炎症细胞浸润无差异。
本研究表明，MMC 有助于预防损伤后 EAC 纤维化。
