癌症免疫编辑与“自发性”肿瘤消退。

Cancer immunoediting and "spontaneous" tumor regression.

机构信息

Colorectal Cancer Genetics, Centre for Academic Surgery, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, Whitechapel, London E1 2AT, UK.

出版信息

Pathol Res Pract. 2010 Jan 15;206(1):1-8. doi: 10.1016/j.prp.2009.10.001. Epub 2009 Nov 27.

DOI:10.1016/j.prp.2009.10.001

PMID:19945228

Abstract

The combination of host protective and tumor-promoting actions of the immune system throughout tumor development is termed cancer immunoediting. This review briefly summarizes the currently vast evidence supporting the immune system's role in not only protecting against developing cancer, but also sculpting tumor immunogenicity and immune escape. We also briefly summarize the history of immunotherapy and discuss the immunoediting process in the context of spontaneous tumor regression and whether this observation can be utilized in future treatment regimens.

摘要

免疫系统在肿瘤发展过程中对宿主的保护作用和促进肿瘤作用的结合被称为癌症免疫编辑。这篇综述简要总结了目前大量支持免疫系统在不仅预防癌症发生，而且塑造肿瘤免疫原性和免疫逃逸方面作用的证据。我们还简要总结了免疫治疗的历史，并讨论了在自发肿瘤消退的背景下免疫编辑过程，以及这一观察结果是否可以用于未来的治疗方案。