高胰岛素血症和糖尿病：小鼠胰岛β细胞代谢-兴奋偶联的遗传学分析。
Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in mice.
机构信息
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Cell Metab. 2009 Dec;10(6):442-53. doi: 10.1016/j.cmet.2009.10.011.
Abstract
The role of metabolism-excitation coupling in insulin secretion has long been apparent, but in recent years, in parallel with studies of human hyperinsulinism and diabetes, genetic manipulation of proteins involved in glucose transport, metabolism, and excitability in mice has brought the central importance of this pathway into sharp relief. We focus on these animal studies and how they provide important insights into not only metabolic and electrical regulation of insulin secretion, but also downstream consequences of alterations in this pathway and the etiology and treatment of insulin-secretion diseases in humans.
摘要
代谢-兴奋偶联在胰岛素分泌中的作用早已显而易见，但近年来，随着对人类高胰岛素血症和糖尿病的研究，以及对涉及葡萄糖转运、代谢和兴奋的蛋白质在小鼠中的遗传操作，这条通路的核心重要性变得更加明显。我们关注这些动物研究，以及它们如何为不仅是胰岛素分泌的代谢和电调节，而且是该途径改变的下游后果以及人类胰岛素分泌疾病的病因和治疗提供重要的见解。
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